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Venkatesh Katari, Ph.D.

PROFESSIONAL SUMMARY

Dr. Katari is a biomedical scientist specializing in endothelial mechanotransduction, angiogenesis, cardiovascular physiology, and neurodegeneration. His research focuses on mechanosensitive ion channels, particularly TRPV4 and Piezo1, and their roles in endothelial signaling, vascular remodeling, angiogenesis, cardiac dysfunction, and neurovascular unit integrity during aging and disease. He has extensive expertise in vascular biology, molecular and cellular physiology, transgenic animal models, advanced imaging, and translational approaches to cardiovascular and neurodegenerative disorders.

AREAS OF EXPERTISE

• TRPV4 mechanotransduction in endothelial autophagy and vascular growth.
• Cardiovascular physiology and pathological cardiac remodeling associated with endothelial dysfunction and fibrosis
• Mechanotransduction pathways regulating angiogenesis and cardiac hypertrophy
• Translational vascular biology using transgenic animal models, advanced imaging, and molecular/cellular physiology approaches
• Neurodegenerative diseases and aging-related pathologies

EDUCATION AND TRAINING

• Ph.D., Biotechnology, Sri Venkateswara Institute of Medical Sciences University, India (2015)
• M.S., Biotechnology, Sri Venkateswara Institute of Medical Sciences University, India (2010)
• B.S., Biotechnology, Sri Venkateswara University, India (2008)

ACADEMIC AND RESEARCH APPOINTMENTS

• Instructor, Physiology and Pharmacology, The University of Toledo, USA, 2025 鈥� Present 听听听听听听听听听听
• Postdoctoral Associate, Physiology and Pharmacology, The University of Toledo, USA, 2021-2025
• Postdoctoral Fellow, Biomedical Sciences, Northeast Ohio Medical University, USA, 2020-2021
• Postdoctoral Fellow, Dept of Neurosciences, Cleveland Clinic, USA, 2019- 2020
• National Postdoctoral Fellow, CBCMT, Vellore Institute of Technology, India, 2016鈥�2019 听
• Senior Research Fellow, Dept of Biotechnology, Sri Venkateswara Institute of Medical Sciences, India, 2011鈥�2015

HONORS / AWARDS / FELLOWSHIPS

• Career Development Award by American Heart Association, 2026
• Dr. Hans G. Folkseen Travel award by Ohio Physiological Society, 2025
• Dr. Peter K Lauf Travel Award by Ohio Physiological Society, 2024
• Dr. Satu Somani Junior Scientist Award in Physiology by ASIOA, USA, 2023听听听听
• Best post award from Ohio Physiological Society (OPS), USA, 2022听听听听
• Best oral presentation award, 9th annual meeting ASIOA, USA, 2021
• Best NPDF poster award, Dept. Science and Technology, India, 2022听听听听听听听听听听听听听听听听
• Young Scientist Travel Grant Dept. Science and Technology, India, 2019
• Best Research Cash award, Vellore Institute of Technology, India, 2018
• National Postdoctoral Fellowship Dept. Science and Technology, India, 2017
• Andhra Pradesh-State Eligible Test (APSET-2014), 2015
• Best Poster award, Sri Venkateswara University, India, 2012
• Biotech Industrial Training Research Fellowship DBT, India, 2010

SERVICE听AND听SOCIETY MEMBERSHIPS

• Admissions听Committee member, The University of Toledo, USA
• Early career member, American Physiological Society, USA
• AHA Professional Member, American Heart association, USA
• Convenor, Association of Scientist of Indian Origin in America (ASIOa), USA
• Life member, Association of Scientist of Indian Origin in America (ASIOa), USA
• PhysPharm Coordinator, Medical Student Research Program, The University of Toledo, USA

EDITORIAL AND REVIEW ACTIVITIES

• Topic Editor, Frontiers of Pharmacology
• Topic Editor, Frontiers of Aging Neuroscience
• Ad-hoc Journal Reviewer, British Journal of Pharmacology, Cellular and Molecular Neurobiology, Cell Biology International, 听听听 Journal of Cellular Physiology, Lipids in Health and Disease, Frontiers in Cardiovascular Medicine, Frontiers in Neurology

GRANT / TRAVEL SUPPORT

Active

1. 26CDA1587519 - Venkatesh Katari (PI) - 04-01-2026 to 03-31-2029
   Title: Mechanical control of endothelial autophagy in angiogenesis
   Role: Principal Investigator (PI); Primary Mentor: Prof. Charles K Thodeti
   Funding Agency: Career Development Award- American Heart Association

Completed

2. Hans G Folkseen Travel award 2025; Funding Agency: Ohio Physiological Society, USA
3. Peter K Lauf Travel award 2024; Funding Agency: Ohio Physiological Society, USA
4. PDF/2016/003652/LS- Venkatesh Katari (PI) -07-01-2017 to 06-31-2019
   Title: Design and development of novel engineered human neural stem cells for the treatment of spinal cord injury: A cell and gene therapy approach
   Funding Agency: Department of Science and Technology (DST-SERB), Govt. of India, Mentor: Dr. Dwaipayan Sen.

5. ITS/2019/000772 鈥� Venkatesh Katari (PI) 04-29-2019 to 05-02-2019
   International Travel support to ASGCT ANNUAL MEETING 2019, USATitle: Regulation of Differentiation of Neural Stem Cells from Human Mesenchymal Stem Cells by MicroRNA

RESEARCH INTERESTS

My research interests focus on vascular biology, cardiovascular physiology, and mechanotransduction, with particular emphasis on the role of mechanosensitive ion channels in endothelial function, angiogenesis, cardiac remodeling, and neurovascular integrity. My work integrates molecular, cellular, and translational approaches to understand how biomechanical signaling regulates vascular homeostasis and contributes to diseases including heart failure and neurodegeneration. My long-term goal is to identify novel mechanotransduction pathways and therapeutic targets that can improve vascular function, tissue regeneration, and healthy aging.

SELECTED PUBLICATIONS

1. Katari V, Dalal K, Kondapalli N, Paruchuri S, Nadiminty N, Thodeti CK. Transient receptor potential vanilloid type 4 channels mediate bladder cancer cell proliferation, migration, and chemoresistance. J Pharmacol Exp Ther. 2025 Sep;392(9):103665.
2. Katari V^#, Dalal K, Kondapalli N, Paruchuri S and Thodeti CK^#. Opioid Receptors in cardiovascular function. Br J Pharmacol. 2025 Aug;182(16):3710-3725 (^#Shared corresponding authors).
3. Katari V^#, Pasupuleti SK, Mullick M, Lekkala VKR, Sen D. Editorial: Advanced neural stem cell therapies for spinal cord injury. Front Pharmacol. 2024;6;15:1469535. (^#Corresponding author).
4. Katari V, Dalal K, Adapala RK, Guarino BD, Kondapalli N, Paruchuri S and Thodeti CK. A TRP to pathological angiogenesis and vascular normalization. Compr Physiol 2024;14 (2), 5389-5406.
5. Dalal KK, Katari V, Kondapalli N, Paruchuri S, Thodeti CK. Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis. Am J Physiol Heart Circ Physiol. 2025 Aug 1;329(2):H340-H357. 2025 Jun 27. (COVER PAGE).
6. Kondapalli, NB^#, Katari V^#, Dalal K, Paruchuri S and Thodeti CK. Angiotensin II induces endothelial dysfunction by downregulating TRPV4 channels. JMCCplus. 2023;6:100055. (^#Shared first authors).
7. Adapala RK^#, Katari V^#, Kanugula AK, Ohanyan V, Paruchuri S, Thodeti CK. Deletion of Endothelial TRPV4 Protects Heart from Pressure Overload-Induced Hypertrophy. Hypertension. 2023;80(11):2345-2356. (^#Shared first authors) (COVER PAGE).
8. Adapala RK^#, Katari V^#, Teegala LR, Thodeti S, Paruchuri S, Thodeti CK. TRPV4 Mechanotransduction in Fibrosis. Cells 2021;6;10(11):3053. (^#Shared first authors).
9. Katari V^#, Ghosh S, Mullick, M Manivasagam G, Sen D^#. Spinal Cord Injury: pathophysiology, treatment strategies, associated challenges, and future implications. Cell Tissue Res 2019; 377:125鈥�151. (^#Shared corresponding authors).
10. Moghal ETB, Baul HS, Katari V, Sen D. Novel miRNA expression in the delta opioid signaling pathway mediated cell survivability in an in vitro model of ER stress. Nanomedicine 2019;17: 150- 187.
11. Reddy A*, Katari V*^#, Sahu S, Roy PS, Datta K, Pearlin, Reddy LVK, Moghal ETB, Mullick M, Rao GHR, Sen D^#. Intron-specific Single Nucleotide Polymorphisms of Fat Mass and Obesity- Associated Gene in Obese and Overweight Individuals of the Indian Adult Population- A Pilot Study. Curr Diabetes Rev. 2019;16(1):84-94 (*shared first author) (^#shared corresponding author).
12. Katari V, Kumari A, Sen D. MicroRNA signature changes during induction of neural stem cells from human mesenchymal stem cells. Nanomedicine 2019;17:94-105.
13. Moghal ETB, Katari V, Sen D. The delta opioid peptide D-Alanine 2, Leucine 5 Enkephaline (DADLE)-induces neuroprotection through cross-talk between the UPR and pro-survival MAPK-NGF- Bcl2 signaling pathways via modulation of several micro-RNAs in SH-SY5Y cells subjected to ER stress. Cell Biol Int. 2018;42(5): 543-569.
14. Katari V, Reddy LVK, Abbas S, Mullick M, Moghal ETB, Balakrishna JP, Sen D. NOTCH Signaling Is Essential for Maturation, Self-Renewal, and Tri- Differentiation of In Vitro Derived Human Neural Stem Cells. Cell Reprogram. 2017;19(6):372-383.
15. Katari V^#, and Sen D^#. 鈥淢esenchymal Stem Cells as a Source of Dopaminergic Neurons: A Potential Cell Based Therapy for Parkinson鈥檚 Disease.鈥� Curr Stem Cell Res Ther 2017;12(4): 326- 347. (^#Shared corresponding authors)
16. Katari V, Srikanth L, Vengamma B, Chandrasekhar C, Prasad BC, Sarma PV. In vitro transdifferentiation of Human cultured CD34+ stem cells into Oligodendrocyte precursors using Thyroid hormones. Neurosci Lett. 2015;588: 36鈥�41.
17. Katari V, Srikanth L, Vengamma B, Chandrasekhar C, Sanjeevkumar A, Mouleshwara Prasad BC, Sarma PV. In vitro differentiation of cultured human CD34+ cells into astrocytes. Neurol India 2013;61: 383-388.
18. Katari V, Srikanth L, Swarupa V, Yeswanth S, Prasad UV, Vasu D, Vishnuvardhan GP, Srinivas P, Santhoshkumar P, Sowjenya G, Nandakumar Y, Chaudhary A, Sarma PVGK. Isolation, purification and characterization of pyruvate kinase from Staphylococcus aureus: a potential drug target. J Clin Sci Res 2012;1:76-82.
19. Katari V, Reiner G, Debral AK, Kirpan P, Reers M, Murthy PVVS, Swarupa V, Srikanth L, Sarma PVGK. pH Optimization and Production of High Potent Cellular Vaccine by Bordetella pertussis. Intl J of Biotechnol and Bioeng Res. 2012;3(1):17-25.